Hello! I travelled about 17hrs on the plane and in total traveled 24-26hrs all together using this medicine cooling bag that I found on amazon. It fit the whole box. It includes 4 gel ice pack that you insert in the box. I recommend putting Humira in a gallon zip block bag so it doesn’t get wet and damped. I also have extra gel ice packs on the outside since I ors traveled for a very long time. Goldwheat Insulin Cooler Travel... https://www.amazon.com/dp/B07CYM3X5Z?ref=ppx_pop_mob_ap_share (I have more info pls dm if possible im new to this app)