Theoretically should work but I often see people asking for sound help in r/retropie with usb speakers. My impression is that they are a bit "fiddly".

Now, if they only get power through USB and the audio goes into them via a separate 3.5mm jack, should be OK.

I would recommend this instead:

https://www.amazon.com/Dell-SoundBar-Speakers-AS510PA-UltraSharp/dp/B003UQP4XO

You can velcro to the back of your marquee pointing down and access the volume knob on it.

If you have a compatible monitor, you don't need the power adapter for it. For example, there's a power jack on the Dell 2007fpb monitors and it's purpose is to power these soundbars. You'll have to do some wire-splicing to make the power-input "pig-tail" coming out of the soundbar reach the jack though.