Bobiverse, its more litRTS but still gives me vibes of the genre and is super 4x in nature. A rich IT manager choses the cryogenic freeze option for health care in case of a life ending situation, so he can be brought out when a cure is available. Instead he is brought out into pseudo-AI serfdom and sent off into space to prepare the universe for humanities expansion.
This series might not be exactly what you're looking for, but it just came to mind...
It's about a guy who is killed in an accident, and later has his brain used (in the far future) to man an AI probe to explore the universe. Bob begins to replicate himself, and many Bobs are born.
At one point one of the bobs discovers an indigenous race on a far planet and become EXTREMELY invested in their future. It's only one of the several aspects to the main story, but it was my favorite part.
It's a very entertaining series, lots of comedy and philosophical dilemmas.