1. Wash and dry your hands with a lint-free towel
2. Clean and condition using ample solution (like Boston) Amazon Link
3. Before applying, fill the reservoir with something like this sterile solution: Another Amazon link
4. I replace every bottle and my lens case monthly as well. I also use the red capped cleaning solution at least once a week.

Edit: My source: I have been using a sclera contact for about 7 years. Had no issues with it till I moved to the Northwest. used to just use the boston solution. After following these instructions, I haven't had a single problem. When I went in to get it checked out, my eye was itchy, irritated and light sensitive. In looking at the ey, my Dr. said it almost looked like a chemical burn. That's when I found I had been doing it wrong for years.