The players always get so angry about characters they aren't allowed to play and break the 'rules'.
Although the best vampire-werewolf i can remember in fiction isn't even from the WoD (it's this crazy druggie murderer). Mostly because the writing is like was reading someone in a constant drug trip.
edit: wow, i spent all this time thinking Samuel was a abomination (vampire-werewolf) only to find he wasn't. I'm almost disappointed.