I have this switch with this USB hub plugged into it. I've got my keyboard, a DAC/Amp, a webcam, and a microphone plugged into it, and it's worked fine so far. I don't have my mouse plugged into it, because I like using a Magic Trackpad for my work MacBook.
Yes. I have mine plugged into a 10 port hub which is plugged into a USB switcher connected to two of my computer (MacBook Pro and a custom built PC). Aside from it taking a few seconds to connect when I switch over to the PC, it has been working great for me for ~4 months.
For reference, here are the exact devices I am running in through: